One of my direct reports (director level, the guy is smart) has been sick for 14 days (fever, cough, oxygen levels dipping below 90, extremely fatigued, unable to work) and missed work for more than a week. His first COVID test came back negative but his fraternity brother is a COVID mocking doctor who found a way to get him Ivermectin prescribed 10 days ago. He has still been getting worse since. He has two young daughters (5 and 3) and was supposed to move to a new house soon. He won't go to the hospital or see a doctor that's not like minded like his friend. Any thoughts on how to convince him to get seen? I've been telling him to do it for his daughters but no luck.
Thank you in advance.
Doc here with actual COVID experience, albeit pediatric. First and foremost, he should go the the hospital and get retested - but even if it is not COVID, he seems to be in a bad spot. He needs medical care. If he is 14 days out and worsening, this is overall a poor predictor of outcome.
The literature on Ivermectin is quite mixed. Even the Cochran database is uncertain after recent meta-analysis. Particularly if looking at only high impact factor journals (consider this as a more rigorous peer review process), there is most likely a trend towards inefficacy, particularly in moderate to severe disease and in courses over 5 days.
Based on what you've said, he is beyond the window for monoclonal antibody therapies. Most literature actually points towards worsening outcomes if hospitalized or requiring oxygen therapy. There are many reasons why this makes sense from a pathophysiology standpoint, but there are still trials working to further clarify this treatment decision.
That being said, ignore the person saying there are no treatment options. That is total bologna.
Immune modulation has become the mainstay of treatment for hospitalized patients and includes steroids (dexamethasone or methylpredisolone) and may include therapies towards augmenting the cytokine cascade (tocilizumab, baricitinib, tofacitinib) if available at your hospital.
Other things to consider that are just purely total body management. While bacterial coinfection is rare, he should have a CXR to evaluate for a focal consolidation. Concomitant medication use needs to be evaluated, he may be on something that needs to be discontinued. From your description, he needs respiratory support and fluid augmentation (he is likely volume depleted after 10 days, particularly if hypoxic for the majority of that time). He needs management of atelectasis. This is typically what is causing hypoxia for COVID patients and may require chest PT, varied positions, and/or positive pressure to assist with alveolar reinflation.
Also, would love to know what kind of "doctor" his friend is.