That's awesome
@MF123 and thanks for sharing. Can you help this dummy out, so these patients were given the anti-malaria drug? Anything else given also in connection with it?
On a side note, My daughter is doing great and thanks for your help there. She is totally free of seizures now including absence ones.
She's been on Ethosuximide 250mg Twice a day and no side effects either.
hey man - really great news about your daughter. Truly. I’m 31 and don’t have kids at the moment, but I can only imagine what you were going through as a parent. It was my pleasure in helping facilitate any kind of help.
Regarding your question - I can’t go into too much detail about treatments etc. I’ll post more on the malaria drug (plaquenil) being used in other studies - I read a lot of the papers already, and yeah the data isn’t there to support it’s widespread use.
Most of the data is from in vitro studies - not in actual human beings.
There are some small studies used in humans but again there are issues with the data. I’ll
Give you this paper as an example - which has been cited by some -
https://www.medrxiv.org/content/10.1101/2020.03.22.20040758v2
-Treatment arms, sample size, endpoints are all different on clinical trials registration website
- Although claims to be blinded placebo-controlled trial this is not described in manuscript
- All patients received the standard treatment (oxygen therapy, antiviral agents, antibacterial agents, and immunoglobulin, with or without corticosteroids) but no further information given
- Only moderate disease (not hypoxic), so not generalizable to hospitalized hypoxic patients
- Definition of fever different than US definition
- Did not report on what baseline temperatures were, use ofantipyretic agents
- Time from onset of symptoms to randomization not listed
- Timing of progression not defined
- Appears no deaths, not clearly stated
- Almost no demographic, comorbidity data given, so cannot assess if groups are similar at baseline. Only sex and age listed
I’ve read the other papers, and issues with the studies are peppered everywhere. Point is that there are a lot of issues with these studies, and most of them - I believe all actual - excluded the sickest patients.
other drugs are being more readily used